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Immune or clearance burden: a rapid wave of dying cells must be cleared, which could stress the system

Significance Statement 7,8-dihydroxyflavone (7,8-DHF) is a drug that has been shown to improve the symptoms of numerous brain disorders including Alzheimers disease and post-traumatic stress disorder in mouse models

20 A gene ontology analysis indicated that SPPEPS upregulated chondrogenesis-related genes such as ENPP1 and CLIC4

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